Gout is characterized by high concentrations of uric acid in the body that can cause an attack of sudden burning pain, stiffness, and swelling in a joint. Gout attacks can happen over and over unless properly treated. Over time, this disorder causes harm to joints, tendons, and other tissues. Excess amount of an enzyme called xanthine oxidase can generate high levels of uric acid and can create crystals in joints and tissues, leading to gout.
Recent research has shown that a tannin-rich extract derived from the edible fruit of the Terminalia bellerica tree helps keep uric acid levels within healthy range.1 This patent-pending, standardized extract from Terminalia bellerica inhibits xanthine oxidase, thus modulating uric acid synthesis.
The bioactive compounds in Terminalia bellerica are also believed to provide a healthy inflammatory response, possibly due to inhibition of inducible nitric oxide synthase (iNOS).
In a 24-week active-control trial, volunteers with elevated uric acid levels who received twice-daily capsules of 500 mg of T. bellerica extract demonstrated decreased uric acid levels by a mean of 27.59%, with no reported adverse side effects. This decrease in uric acid levels enabled 88.8% of the people in the study arm who were taking the extract to achieve targeted uric acid serum levels.1