Glycyrrhizic acid (from Licorice root extract): Glycyrrhetinic acid (metabolite of glycyrrhizic acid) binds 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2) to inhibit the breakdown of cortisol (1,2)*
L-histidine: Precursor to histamine. In the central nervous system, histamine plays an important role in the release of pituitary hormones and wakefulness (3).
L-methionine: Precursor to S-adenosylmethionine (SAMe) (4). SAMe is directly involved in methylation processes including catecholamine synthesis (5).
L-tyrosine: Precursor to catecholamines including dopamine, norepinephrine, and epinephrine.
Rhodiola rosea root extract (5% rosavins): Adaptogen that has been shown to reduce stress-induced effects (6,7).* In a randomized, double-blind, placebo-controlled study, Rhodiola rosea was shown to significantly improve mental fatigue and general well-being under stress (7).*
Green tea leaf extract (Camellia sinensis) (65% EGCG): Epigallocatechin gallate (EGCG) is a polyphenol in green tea that provides antioxidant protection by its ability to scavenge free radicals and metal ions (8)* EGCG has been shown to increase resistance to fatigue in vivo (9).*
Vitamins B and C: Active forms of pantothenic acid, niacin, B6, folate, B12, and C are important for the synthesis of adrenal hormones and neurotransmitters (10-14).*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.